A kidney biopsy, also called a renal biopsy, is a test doctors may use alongside blood and urine tests to learn more about how your kidneys function. There are several types of kidney biopsies, but they all involve collecting a small amount of kidney tissue for a pathologist to examine closely in a lab.
As you await the results of a kidney biopsy, you might wonder what the report will show. A kidney biopsy can reveal a lot about your kidney health. This test can also be a pivotal step in choosing the right treatment for various kidney diseases.
Here’s a quick rundown of what kidney biopsies can mean and what to expect.
First, a nephrologist (kidney specialist) or radiologist collects a sample of your kidney tissue using a hollow needle. They then deliver the sample to a lab for a pathologist to examine it.
A pathologist is a medical doctor who specializes in studying body tissue and fluids. They process the tissue and examine it under a microscope for signs of damage or disease.
The results of a kidney biopsy go beyond just “normal” or “abnormal.” Instead, the pathologist looks for any abnormalities in the tissue and describes them in a report.
The pathologist’s findings can say a lot about your kidney health and how well your kidneys are currently functioning. Your kidney biopsy can tell you:
Your kidney biopsy report gives you details about the damage or disease found in your kidney sample. Your doctor will explain what your results mean in full detail and in the context of your overall health.
Many kidney diseases involve inflammation in the kidneys. Called nephritis, this swelling can interfere with the kidney’s ability to filter blood properly.
Long-term kidney inflammation can cause scar tissue to replace healthy tissue. Scar tissue in the kidneys may be irreversible and can eventually lead to kidney failure.
In kidney diseases like immunoglobulin A nephropathy (IgAN), abnormal immune proteins called immunoglobulin build up in kidney tissue. This buildup can damage the kidneys and lead to serious complications. The only way your doctor can be sure you have IgAN is by doing a kidney biopsy.
Your kidney biopsy results could show signs of an infection in your kidney. However, you don’t need a biopsy to find some infections. Blood or urine tests can often show signs of an infection earlier so you can get treated sooner.
The pathologist examining your kidney biopsy sample will report other abnormalities they see when examining the tissue, such as signs of a complement-mediated kidney disease like C3 glomerulopathy, which can involve genetic factors, acquired immune abnormalities, or other triggers. They may also compare their findings to past biopsies to monitor kidney disease progression or determine how well treatments are working.
You can expect to wait a few days to hear back from your doctor after your kidney biopsy. They’ll contact you to schedule a follow-up visit. At that appointment, they will explain the findings of the report to you and answer any questions you may have.
In some cases, kidney biopsy results may arrive a little earlier. If there’s an urgent concern with your kidney health, you might get preliminary kidney biopsy results by the next day. However, it may still take the pathologist a few days to complete the final report.
Kidney biopsy results alone typically aren’t enough to make final decisions about your diagnosis or treatment. You’ll work closely with your doctor to make decisions about your kidney health based on the results of your biopsy and other tests.
Your doctor may adjust your treatment or create a new treatment plan according to the results of your tests.
Beyond the pathologist’s report, your doctor may consider:
In some cases, kidney biopsy results may not give your doctor enough information to make a diagnosis or guide your treatment plan. In these cases, the kidney biopsy is considered inconclusive.
If your kidney biopsy is inconclusive, your doctor may recommend further tests to gather more information about your kidney health and function. Additional tests might include genetic testing, another kidney biopsy, or another type of kidney imaging, such as a CT scan or ultrasound.
If you have an upcoming kidney biopsy, discuss any additional questions or concerns you may have with your doctor. Your doctor can help you prepare physically and mentally for your kidney biopsy by telling you how to prepare, what to expect during the procedure, and how the results might affect your treatment plan.
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