Can kidney disease be inherited?
Yes, some types of kidney disease are hereditary. About 80 percent of all rare kidney diseases are inherited, meaning they're passed down through families due to genetic mutations.
In hereditary kidney disease, faulty genes with mutations can affect kidney function. These genes are passed from Show Full Answer
Can kidney disease be inherited?
Yes, some types of kidney disease are hereditary. About 80 percent of all rare kidney diseases are inherited, meaning they're passed down through families due to genetic mutations.
In hereditary kidney disease, faulty genes with mutations can affect kidney function. These genes are passed from parent to child, causing the body to make defective or missing versions of certain proteins that the kidneys need to work properly.
However, it's important to note that not all kidney disease is hereditary. Chronic kidney disease (CKD) usually develops in people with diabetes or high blood pressure, where high blood sugar and blood pressure levels damage the kidneys over time. Common hereditary kidney diseases include:
- Polycystic kidney disease (PKD) - The most common genetic kidney disease, affecting 1 in 400 to 1,000 people
- Alport syndrome - Affects about 1 in 50,000 people worldwide
- Fabry disease - More common in men due to how it's inherited
- Cystinosis - Symptoms typically begin in babies
- APOL1-mediated kidney disease - Increases risk of certain kidney diseases
If you have a family history of kidney disease, genetic testing can help identify specific mutations. This only requires a blood or saliva sample and can help guide treatment and inform other family members about their risk.
October 29, 2025
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